Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.5
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9.5
We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
Read More
9.5
We explored the potential of Silybum marianum (SM) in combating cardiac lipotoxicity following myocardial infarction (MI) in a pig study. Over 10 days, animals received either SM or a placebo.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
Read More
9
Milk thistle aids heart recovery
We explored how Silybum marianum, or milk thistle, can affect heart health, especially after a heart attack. In studies on pigs, we found that giving SM shortly before and after a heart attack helped reduce damage and improve recovery.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
Read More
Most Useful Reviews
7.5
Positive heart health
Vitamin D3 is essential for regulating calcium and phosphorus levels, which helps maintain healthy bones and teeth. It plays a crucial role in bone health, with deficiencies leading to osteoporosis in adults and rickets in children. Vitamin D3 supports the immune system, crucial for fighting infections; a lack of it can diminish disease resistance. Additionally, studies suggest it may positively influence cardiovascular health, reducing the risk of heart disease. Furthermore, it can affect serotonin levels in the brain, impacting mood regulation. Deficiency in this vitamin has been associated with an increased risk of depression and anxiety disorders.
Read More
7.5
Lifespan extension
Glutathione is recommended for various health conditions, including Parkinson’s and heart disease. Experts are optimistic about its potential to extend lifespan, boost immunity, improve strength and physical performance, and reduce the risk of age-related diseases. I personally create my own liposomal form using Now Glutathione.
Read More
6
Immune system aid
Glutathione plays a crucial role in tissue building and repair, synthesising necessary chemicals and proteins, and supporting immune system function. Many individuals take glutathione for concerns such as anti-ageing, alcohol use disorder, liver disease, heart disease, and other health issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.5
- All Researches
9.5
We explored the potential of Silybum marianum (SM) in combating cardiac lipotoxicity following myocardial infarction (MI) in a pig study. Over 10 days, animals received either SM or a placebo.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
Read More
9.5
We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
Read More
9
Milk thistle aids heart recovery
We explored how Silybum marianum, or milk thistle, can affect heart health, especially after a heart attack. In studies on pigs, we found that giving SM shortly before and after a heart attack helped reduce damage and improve recovery.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
Read More
8
We explored the effects of silymarin on heart and liver health in a study involving 28 male mice. The animals were divided into groups and treated with silymarin, saline, and paracetamol to simulate oxidative stress.
The results showed that silymarin significantly reduced liver damage and inflammation caused by paracetamol and also demonstrated protective effects in cardiac tissue. While these findings highlight its potential as a treatment for heart and liver issues, further research is needed to confirm how effective silymarin is in humans.
The results showed that silymarin significantly reduced liver damage and inflammation caused by paracetamol and also demonstrated protective effects in cardiac tissue. While these findings highlight its potential as a treatment for heart and liver issues, further research is needed to confirm how effective silymarin is in humans.
Read More
8
We explored how 2,3-dehydrosilybin (DHS), a component of Silybum marianum, may protect heart cells from damage caused by a lack of oxygen. The study involved cultured rat heart cells subjected to hypoxia and reoxygenation, which is a common stress for heart tissue. Our findings revealed that while DHS treatment reduced the harmful production of reactive oxygen species, it did not improve cell viability. Thus, while DHS offers some protective effects, significant benefits for heart health remain unconfirmed.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Positive heart health
Vitamin D3 is essential for regulating calcium and phosphorus levels, which helps maintain healthy bones and teeth. It plays a crucial role in bone health, with deficiencies leading to osteoporosis in adults and rickets in children. Vitamin D3 supports the immune system, crucial for fighting infections; a lack of it can diminish disease resistance. Additionally, studies suggest it may positively influence cardiovascular health, reducing the risk of heart disease. Furthermore, it can affect serotonin levels in the brain, impacting mood regulation. Deficiency in this vitamin has been associated with an increased risk of depression and anxiety disorders.
Read More
7.5
Lifespan extension
Glutathione is recommended for various health conditions, including Parkinson’s and heart disease. Experts are optimistic about its potential to extend lifespan, boost immunity, improve strength and physical performance, and reduce the risk of age-related diseases. I personally create my own liposomal form using Now Glutathione.
Read More
6
Immune system aid
Glutathione plays a crucial role in tissue building and repair, synthesising necessary chemicals and proteins, and supporting immune system function. Many individuals take glutathione for concerns such as anti-ageing, alcohol use disorder, liver disease, heart disease, and other health issues.
Read More
Frequently Asked Questions
7.5
Positive heart health
Vitamin D3 is essential for regulating calcium and phosphorus levels, which helps maintain healthy bones and teeth. It plays a crucial role in bone health, with deficiencies leading to osteoporosis in adults and rickets in children. Vitamin D3 supports the immune system, crucial for fighting infections; a lack of it can diminish disease resistance. Additionally, studies suggest it may positively influence cardiovascular health, reducing the risk of heart disease. Furthermore, it can affect serotonin levels in the brain, impacting mood regulation. Deficiency in this vitamin has been associated with an increased risk of depression and anxiety disorders.
6
Immune system aid
Glutathione plays a crucial role in tissue building and repair, synthesising necessary chemicals and proteins, and supporting immune system function. Many individuals take glutathione for concerns such as anti-ageing, alcohol use disorder, liver disease, heart disease, and other health issues.
7.5
Lifespan extension
Glutathione is recommended for various health conditions, including Parkinson’s and heart disease. Experts are optimistic about its potential to extend lifespan, boost immunity, improve strength and physical performance, and reduce the risk of age-related diseases. I personally create my own liposomal form using Now Glutathione.
9.5
We explored the potential of Silybum marianum (SM) in combating cardiac lipotoxicity following myocardial infarction (MI) in a pig study. Over 10 days, animals received either SM or a placebo.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
9.5
We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
8
We investigated how a mix of five medicinal plants, including Silybum marianum (milk thistle), impacts heart cells under oxidative stress. Our results showed that this blend can activate a key protein called Nrf2, which helps enhance the body’s antioxidant defenses. In lab-grown heart cells, we found that treating them with our phytochemical formula not only boosted Nrf2 activity but also protected these cells from damage caused by oxidants. It appears that this protective effect largely relies on Nrf2, highlighting the potential of these plants in heart disease management.
References
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520
- Vilahur G, Sutelman P, Mendieta G, Ben-Aicha S, Borrell-Pages M, et al. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. Atherosclerosis. 2021;324:91. doi:10.1016/j.atherosclerosis.2021.03.014
- Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. doi:10.1016/j.fitote.2018.10.028
- Vilahur G, Casaní L, Peña E, Crespo J, Juan-Babot O, et al. Silybum marianum provides cardioprotection and limits adverse remodeling post-myocardial infarction by mitigating oxidative stress and reactive fibrosis. Int J Cardiol. 2018;270:28. doi:10.1016/j.ijcard.2018.06.030
- Gabrielová E, Křen V, Jabůrek M, Modrianský M. Silymarin component 2,3-dehydrosilybin attenuates cardiomyocyte damage following hypoxia/reoxygenation by limiting oxidative stress. Physiol Res. 2015;64:79.
- Reuland DJ, Khademi S, Castle CJ, Irwin DC, McCord JM, et al. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Free Radic Biol Med. 2013;56:102. doi:10.1016/j.freeradbiomed.2012.11.016
- Anestopoulos I, Kavo A, Tentes I, Kortsaris A, Panayiotidis M, et al. Silibinin protects H9c2 cardiac cells from oxidative stress and inhibits phenylephrine-induced hypertrophy: potential mechanisms. J Nutr Biochem. 2013;24:586. doi:10.1016/j.jnutbio.2012.02.009
- Rašković A, Stilinović N, Kolarović J, Vasović V, Vukmirović S, et al. The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats. Molecules. 2011;16:8601. doi:10.3390/molecules16108601
